Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters.

ABSTRACT: Central insulin is critically involved in the regulation of hedonic feeding. Insulin resistance in overweight has recently been shown to reduce the inhibitory function of insulin in the human brain. How this relates to effective weight management is unclear, especially in older people, who are highly vulnerable to hyperinsulinemia and in whom neural target systems of insulin action undergo age-related changes. Here, 50 overweight, non-diabetic older adults participated in a double-blind, placebo-controlled, pharmacological functional magnetic resonance imaging study before and after randomization to a 3-month caloric restriction or active waiting group. Our data show that treatment outcome in dieters can be predicted by baseline measures of individual intranasal insulin (INI) inhibition of

SUBMITTER: Tiedemann LJ 

PROVIDER: S-EPMC9519148 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature