A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development.

ABSTRACT: Mechanisms that control 'beige/brite' thermogenic adipose tissue development may be harnessed to improve human metabolic health. To define these mechanisms, we developed a species-hybrid model in which human mesenchymal progenitor cells were used to develop white or thermogenic/beige adipose tissue in mice. The hybrid adipose tissue developed distinctive features of human adipose tissue, such as larger adipocyte size, despite its neurovascular architecture being entirely of murine origin. Thermogenic adipose tissue recruited a denser, qualitatively distinct vascular network, differing in genes mapping to circadian rhythm pathways, and denser sympathetic innervation. The enhanced thermogenic neurovascular network was associated with human adipocyte expression of THBS4, TNC,

SUBMITTER: Solivan-Rivera J 

PROVIDER: S-EPMC9519151 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature