Pediatric ¹²⁹ Xe Gas-Transfer MRI-Feasibility and Applicability.

ABSTRACT:

Background

¹²⁹ Xe gas-transfer MRI provides regional measures of pulmonary gas exchange in adults and separates xenon in interstitial lung tissue/plasma (barrier) from xenon in red blood cells (RBCs). The technique has yet to be demonstrated in pediatric populations or conditions.

Purpose/hypothesis

To perform an exploratory analysis of ¹²⁹ Xe gas-transfer MRI in children.

Study type

Prospective.

Population

Seventy-seven human volunteers (38 males, age = 17.7 ± 15.1 years, range 5-68 years, 16 healthy). Four pediatric disease cohorts.

Field strength/sequence

3-T, three-dimensional-radial one-point Dixon Fast Field Echo (FFE) Ultrashort Echo Time (UTE).

Assessment

Breath hold compliance was assessed by quantitative signal-to-n

SUBMITTER: Willmering MM 

PROVIDER: S-EPMC9519191 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature