Identification of Monocyte-Associated Genes Related to the Instability of Atherosclerosis Plaque.

ABSTRACT:

Background

Atherosclerotic plaque instability is a common cause of stroke and ischemic infarction, and identification of monocyte-associated genes has become a prominent feature in cardiovascular research as a contributing/predictive marker.

Methods

Whole genome sequencing data were downloaded from GSE159677, GSE41571, GSE120521, and GSE118481. Single-cell sequencing data analysis was conducted to cluster molecular subtypes of atherosclerotic plaques and identify specific genes. Differentially expressed genes (DEGs) between normal subjects and patients with unstable atheromatous plaques were screened. Weighted gene coexpression network analysis (WGCNA) was performed to find key module genes. In addition, GO and KEGG enrichment analyses explored potential biological signaling

SUBMITTER: Qin W 

PROVIDER: S-EPMC9519342 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature