PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM.

ABSTRACT:

Background

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm and often acquires chemoresistance by increasing stemness in tumour tissue, thereby generating cancer stem cells (CSCs). CSCs escape treatment by deploying metabolic pathways to trigger dormancy or proliferation, also gaining the ability to exit and re-enter the cell cycle to hide their cellular identity.

Methods

We employed various cellular and biochemical assays to identify the role of the glycolytic enzyme PFKFB3, by knocking it down and pharmacologically inhibiting it with PFK158, to determine its anticancer effects in vitro and in vivo by targeting the CSC population in MPM.

Results

Here, we have identified PFKFB3 as a strategic player to target the CSC population in MPM and demonstrated th

SUBMITTER: Sarkar Bhattacharya S 

PROVIDER: S-EPMC9519537 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature