Multiscale modeling of collective cell migration elucidates the mechanism underlying tumor–stromal interactions in different spatiotemporal scales

ABSTRACT: Metastasis is the pathogenic spread of cancer cells from a primary tumor to a secondary site which happens at the late stages of cancer. It is caused by a variety of biological, chemical, and physical processes, such as molecular interactions, intercellular communications, and tissue-level activities. Complex interactions of cancer cells with their microenvironment components such as cancer associated fibroblasts (CAFs) and extracellular matrix (ECM) cause them to adopt an invasive phenotype that promotes tumor growth and migration. This paper presents a multiscale model for integrating a wide range of time and space interactions at the molecular, cellular, and tissue levels in a three-dimensional domain. The modeling procedure starts with presenting nonlinear dynamics of cancer cells and

SUBMITTER: Heidary Z 

PROVIDER: S-EPMC9519582 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature