Immune and inflammation: related factor alterations as biomarkers for predicting prognosis and responsiveness to PD-1 monoclonal antibodies in cervical cancer.

ABSTRACT:

Purpose

We aimed to elucidate the potential mechanisms of effective responsiveness to PD-1 monoclonal antibody and evaluate more reliable biomarkers to improve the ability to predict the populations of cervical cancer (CC) suitable for immunotherapy.

Methods

Peripheral blood samples of CC patients undergoing anti-PD-1 therapy were collected before and after treatment. Differentially expressed genes (DEGs) were analyzed between partial response (PR) and progressive disease (PD) patients. A novel prognostic inflammation and immune-related response gene (IRRG) model was constructed and its prognostic role, correlation with tumor immunity and tumor mutation were evaluated.

Results

DEGs in PR patient after treatment could predict the response to PD-1 monoclonal antibodies.

SUBMITTER: Liu X 

PROVIDER: S-EPMC9519820 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature