Mathematical model of insulin kinetics accounting for the amino acids effect during a mixed meal tolerance test.

ABSTRACT: Amino acids (AAs) are well known to be involved in the regulation of glucose metabolism and, in particular, of insulin secretion. However, the effects of different AAs on insulin release and kinetics have not been completely elucidated. The aim of this study was to propose a mathematical model that includes the effect of AAs on insulin kinetics during a mixed meal tolerance test. To this aim, five different models were proposed and compared. Validation was performed using average data, derived from the scientific literature, regarding subjects with normal glucose tolerance (CNT) and with type 2 diabetes (T2D). From the average data of the CNT and T2D people, data for two virtual populations (100 for each group) were generated for further model validation. Among the five proposed models, a

SUBMITTER: Morettini M 

PROVIDER: S-EPMC9519856 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature