In-depth insights into cervicovaginal microbial communities and hrHPV infections using high-resolution microbiome profiling.

ABSTRACT: The cervicovaginal microbiome (CVM) correlates with women's cervical health, and variations in its composition are associated with high-risk human papillomavirus (hrHPV) infection outcomes. Cervicovaginal microbes have been grouped into five community state types (CSTs) based on microbial community composition and abundance. However, studying the impact of CSTs in health and disease is challenging because the current sequencing technologies have limited confident discrimination between closely related and yet functionally different bacterial species. Circular probe-based RNA sequencing (ciRNAseq) achieves high-resolution microbiome profiling and therefore provides in-depth and unambiguous knowledge about the composition of the CVM. Based on ciRNAseq profiling of a large cohort of cervical

SUBMITTER: Molina MA 

PROVIDER: S-EPMC9519886 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature