Robust association tests for quantitative traits on the X chromosome.

ABSTRACT: The genome-wide association study is an elementary tool to assess the genetic contribution to complex human traits. However, such association tests are mainly proposed for autosomes, and less attention has been given to methods for identifying loci on the X chromosome due to their distinct biological features. In addition, the existing association tests for quantitative traits on the X chromosome either fail to incorporate the information of males or only detect variance heterogeneity. Therefore, we propose four novel methods, which are denoted as QXcat, QZ_max, QMVX_cat and QMVZ_max. When using these methods, it is assumed that the risk alleles for females and males are the same and that the locus being studied satisfies the generalized genetic model for fema

SUBMITTER: Yang ZY 

PROVIDER: S-EPMC9519943 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature