Increased cytotoxic T-cells in the airways of adults with former bronchopulmonary dysplasia.

ABSTRACT:

Rationale

Bronchopulmonary dysplasia (BPD) in preterm-born infants is a risk factor for chronic airway obstruction in adulthood. Cytotoxic T-cells are implicated in COPD, but their involvement in BPD is not known.

Objectives

To characterise the distribution of airway T-cell subsets in adults with a history of BPD.

Methods

Young adults with former BPD (n=22; median age 19.6 years), age-matched adults born preterm (n=22), patients with allergic asthma born at term (n=22) and healthy control subjects born at term (n=24) underwent bronchoalveolar lavage (BAL). T-cell subsets in BAL were analysed using flow cytometry.

Results

The total number of cells and the differential cell counts in BAL were similar among the study groups. The percentage of CD3⁺CD8

SUBMITTER: Um-Bergstrom P 

PROVIDER: S-EPMC9520031 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature