Gut dysbiosis and inflammatory blood markers precede HIV with limited changes after early seroconversion.

ABSTRACT:

Background

Alterations in the gut microbiome have been associated with HIV infection, but the relative impact of HIV versus other factors on the gut microbiome has been difficult to determine in cross-sectional studies.

Methods

To address this, we examined the gut microbiome, serum metabolome, and cytokines longitudinally within 27 individuals before and during acute HIV using samples collected from several ongoing cohort studies. Matched control participants (n=28) from the same cohort studies without HIV but at similar behavioral risk were used for comparison.

Findings

We identified few changes in the microbiome during acute HIV infection, but did find alterations in serum metabolites involving secondary bile acid (lithocholate sulfate, glycocholenate sulfate) and a

SUBMITTER: Fulcher JA 

PROVIDER: S-EPMC9520213 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature