Association of adenosine signaling gene signature with estrogen receptor-positive breast and prostate cancer bone metastasis.

ABSTRACT: Bone metastasis is a common and devastating consequence of several major cancer types, including breast and prostate. Osteocytes are the predominant bone cell, and through connexin (Cx) 43 hemichannels release ATP to the bone microenvironment that can be hydrolyzed to adenosine. Here, we investigated how genes related to ATP paracrine signaling are involved in two common bone-metastasizing malignancies, estrogen receptor positive (ER⁺) breast and prostate cancers. Compared to other sites, bone metastases of both cancer types expressed higher levels of ENTPD1 and NT5E, which encode CD39 and CD73, respectively, and hydrolyze ATP to adenosine. ADORA3, encoding the adenosine A3 receptor, had a similar expression pattern. In primary ER⁺ breast cancer, high levels of the tr

SUBMITTER: Shropshire DB 

PROVIDER: S-EPMC9520286 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature