Treatment Utilization and Outcomes for Locally Advanced Rectal Cancer in Older Patients.

ABSTRACT:

Importance

The number of older patients (80 years and older) diagnosed with locally advanced rectal cancer (LARC) is expected to increase. Although current guidelines recommend neoadjuvant chemoradiation therapy (NACRT) followed by resection, little is known about management and outcomes in this older population.

Objective

To assess the trends in management of older patients diagnosed with LARC who had a surgical resection.

Design, setting, and participants

Patients 80 years and older who had a surgical resection for LARC were identified in the 2004-2016 National Cancer Database. Patients were grouped based on therapy sequence: (1) surgery followed by adjuvant therapy (AT), ie, chemotherapy or radiation; (2) surgery alone; or (3) NACRT followed by surgical resection.

SUBMITTER: Nassoiy S 

PROVIDER: S-EPMC9520439 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature