Identifying shared genetic loci between coronavirus disease 2019 and cardiovascular diseases based on cross-trait meta-analysis.

ABSTRACT: People with coronavirus disease 2019 (COVID-19) have different mortality or severity, and this clinical outcome is thought to be mainly attributed to comorbid cardiovascular diseases. However, genetic loci jointly influencing COVID-19 and cardiovascular disorders remain largely unknown. To identify shared genetic loci between COVID-19 and cardiac traits, we conducted a genome-wide cross-trait meta-analysis. Firstly, from eight cardiovascular disorders, we found positive genetic correlations between COVID-19 and coronary artery disease (CAD, R _g = 0.4075, P = 0.0031), type 2 diabetes (T2D, R _g = 0.2320, P = 0.0043), obesity (OBE, R _g = 0.3451, P = 0.0061), as well as hypertension (HTN, R <

SUBMITTER: Guo H 

PROVIDER: S-EPMC9520490 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature