Ginsenoside Rc ameliorated atherosclerosis via regulating gut microbiota and fecal metabolites.

ABSTRACT: Atherosclerosis (AS) and the accompanied cardiovascular diseases (CVDs) were the leading cause of death worldwide. Recently, the association between CVDs, gut microbiota, and metabolites had aroused increasing attention. In the study, we headed our investigation into the underlying mechanism of ginsenoside Rc (GRc), an active ingredient of ginsenosides used for the treatment of CVDs, in apolipoprotein E-deficient (ApoE^-/-) mice with high-fat diet (HFD). Seven-week-old male ApoE^-/- mice were randomly divided into four groups: the normal control (NC) group, the HFD group, the GRc group (40 mg/kg/d), and the atorvastatin (Ato) group (10 mg/kg/d). Atherosclerotic injury was evaluated by aortic lesions, serum lipid levels, and inflammatory factors. The composition of gut m

SUBMITTER: Xie B 

PROVIDER: S-EPMC9520581 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature