Tablet Formulation of 2-((3-(Chloromethyl)benzoyl)oxy)benzoic Acid by Linear and Quadratic Models.

ABSTRACT:

Purpose

This research determines the effect of sodium lauryl sulfate (SLS) as a surfactant, croscarmellose sodium (CS) as a disintegrating agent, and SLS-CS combinations on 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid (3CH₂Cl) (log P = 3.73) tablet formulations. In addition, this study aims to determine the optimum of the 3CH₂Cl tablet formula.

Methods

The tablets are manufactured through direct compression according to the simplex lattice design. The optimal SLS and CS concentration was determined in vitro using linear and quadratic models to achieve better tablet disintegration and dissolution.

Results

The same linear and quadratic coefficient profiles of SLS and CS indicate that the combined coefficient of SLS-CS with a quadratic model

SUBMITTER: Hadinugroho W 

PROVIDER: S-EPMC9520729 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature