Rat tail models for the assessment of injectable nucleus pulposus regeneration strategies.

ABSTRACT: Back pain is a global epidemiological and socioeconomic problem often associated with intervertebral disc degeneration; a condition believed to initiate in the nucleus pulposus (NP). There is considerable interest in developing early therapeutic interventions to target the NP and halt degeneration. Rat caudal models of disc degeneration have demonstrated significant utility in the study of disease progression and its impact on tissue structure, composition, and mechanical performance. One significant advantage of the caudal model is the ease of access and high throughput nature. However, considerable variability exists across the literature in terms of experimental setup and parameters. The objective of this article is to aid researchers in the design and development of caudal puncture mod

SUBMITTER: Barcellona MN 

PROVIDER: S-EPMC9520766 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature