Clinical impact of microbleeds in patients with Alzheimer's disease.

ABSTRACT:

Introduction

Cerebral microbleeds (CMBs) are more frequent in patients with Alzheimer's disease (AD) than in the general population. However, their clinical significance remains poorly understood. We carried out a multimodal approach to evaluate the impact of CMBs at a clinical, neuropsychological, and survival level, as well as on core AD biomarkers in the cerebrospinal fluid (CSF) in AD patients.

Methods

We prospectively recruited 98 patients with mild-moderate AD. At baseline, they underwent brain MRI, and AD CSF biomarkers and APOE genotypes were analysed. An extensive neuropsychological battery was performed at baseline and after 1 year of follow-up. We analysed the stroke incidence and mortality with survival analyses.

Results

Forty-eight (48.5%) patients had at

SUBMITTER: Vazquez-Justes D 

PROVIDER: S-EPMC9520821 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature