African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.

ABSTRACT:

Background

Asthma is the most common chronic disease in children, occurring at higher frequencies and with more severe disease in children with African ancestry.

Methods

We tested for association with haplotypes at the most replicated and significant childhood-onset asthma locus at 17q12-q21 and asthma in European American and African American children. Following this, we used whole-genome sequencing data from 1060 African American and 100 European American individuals to identify novel variants on a high-risk African American-specific haplotype. We characterized these variants in silico using gene expression and ATAC-seq data from airway epithelial cells, functional annotations from ENCODE, and promoter capture (pc)Hi-C maps in airway epithelial cells. Candidate causal vari

SUBMITTER: Washington C 

PROVIDER: S-EPMC9520885 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature