Induced pluripotent stem cell-derived brain organoids as potential human model system for chemotherapy induced CNS toxicity.

ABSTRACT: Neurotoxic phenomena are among the most common side effects of cytotoxic agents. The development of chemotherapy-induced polyneuropathy (CIPN) is a well-recognized adverse reaction in the peripheral nervous system, while changes of cognitive functions (post-chemotherapy cognitive impairment (PCCI)) are more diffuse and have only recently drawn scientific interest. PCCI in patients most often displays as short-term memory loss, reduced multitasking ability or deficits in language. Not least, due to a lack of preclinical human model systems, the underlying molecular mechanisms are poorly understood, and treatments are missing. We thus investigated whether induced pluripotent stem cell (iPSC)-derived brain organoids can serve as a human model system for the study of chemotherapy induced centr

SUBMITTER: Scholz S 

PROVIDER: S-EPMC9520921 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature