Single-cell analysis of immune cell transcriptome during HIV-1 infection and therapy.

ABSTRACT:

Background

Cellular immune responses are phenotypically and functionally perturbed during HIV-1 infection, with the majority of function restored upon antiretroviral therapy (ART). Despite ART, residual inflammation remains that can lead to HIV-related co-morbidities and mortality, indicating that ART does not fully restore normal immune cell function. Thus, understanding the dynamics of the immune cell landscape during HIV-1 infection and ART is critical to defining cellular dysfunction that occurs during HIV-1 infection and imprints during therapy.

Results

Here, we have applied single-cell transcriptome sequencing of peripheral blood immune cells from chronic untreated HIV-1 individuals, HIV-1-infected individuals receiving ART and HIV-1 negative individuals. We also appli

SUBMITTER: Pollara J 

PROVIDER: S-EPMC9520965 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature