Comparing Retinal Structure in Patients with Achromatopsia and Blue Cone Monochromacy Using OCT.

ABSTRACT:

Purpose

To compare foveal hypoplasia and the appearance of the ellipsoid zone (EZ) at the fovea in patients with genetically confirmed achromatopsia (ACHM) and blue cone monochromacy (BCM).

Design

Retrospective, multi-center observational study.

Subjects

Molecularly confirmed patients with ACHM (n = 89) and BCM (n = 33).

Methods

We analyzed high-resolution spectral domain optical coherence tomography (SD-OCT) images of the macula from aforementioned patients with BCM. Three observers independently graded SD-OCT images for foveal hypoplasia (i.e. retention of one or more inner retinal layers at the fovea) and four observers judged the integrity of the EZ at the fovea, based on an established grading scheme. These measures were compared with previously published

SUBMITTER: Patterson EJ 

PROVIDER: S-EPMC9521040 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature