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FDA Emergency Use Authorization-Approved Novel Coronavirus Disease 2019, Pressure-Regulated, Mechanical Ventilator Splitter That Enables Differential Compliance Multiplexing.


ABSTRACT: Infection with the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may cause viral pneumonia and acute respiratory distress syndrome (ARDS). Treatment of ARDS often requires mechanical ventilation and may take weeks for resolution. In areas with a large outbreaks, there may be shortages of ventilators available. While rudimentary methods for ventilator splitting have been described, given the range of independent ventilatory settings required for each patient, this solution is suboptimal. Here, we describe a device that can split a ventilator among up to four patients while allowing for individualized settings. The device has been validated in vitro and in vivo.

SUBMITTER: Paulsen MJ 

PROVIDER: S-EPMC9521388 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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FDA Emergency Use Authorization-Approved Novel Coronavirus Disease 2019, Pressure-Regulated, Mechanical Ventilator Splitter That Enables Differential Compliance Multiplexing.

Paulsen Michael J MJ   Zhu Yuanjia Y   Park Matthew H MH   Imbrie-Moore Annabel M AM   Baker Sam S   Walter Edmonston David D   Dawson Tyler T   Ly Evan E   Martin Bell Shannon S   Tran Nick A NA   Jung Jinsuh J   Cedarleaf-Pavy Jordan J   Sridhar K R KR   Venkataraman Venkat V   Woo Y Joseph YJ  

ASAIO journal (American Society for Artificial Internal Organs : 1992) 20220603 10


Infection with the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may cause viral pneumonia and acute respiratory distress syndrome (ARDS). Treatment of ARDS often requires mechanical ventilation and may take weeks for resolution. In areas with a large outbreaks, there may be shortages of ventilators available. While rudimentary methods for ventilator splitting have been described, given the range of independent ventilatory settings required for each patient, th  ...[more]

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