Factors Associated With COVID-19 Vaccine Response in Transplant Recipients: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

The rapid development and universal access to vaccines represent a milestone in combating the coronavirus disease 2019 (COVID-19) pandemic. However, there are major concerns about vaccine response in immunocompromised populations in particular transplant recipients. In the present study, we aim to comprehensively assess the humoral response to COVID-19 vaccination in both orthotopic organ transplant and allogeneic hematopoietic stem cell transplant recipients.

Methods

We performed a systematic review and meta-analysis of 96 studies that met inclusion criteria.

Results

The pooled rates of seroconversion were 49% (95% confidence interval [CI], 43%-55%) in transplant recipients and 99% (95% CI, 99%-99%) in healthy controls after the second dose of vaccine. The

SUBMITTER: Li J 

PROVIDER: S-EPMC9521391 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature