Regional Brain and Spinal Cord Volume Loss in Spinocerebellar Ataxia Type 3.

ABSTRACT:

Background

Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity.

Objective

The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease.

Methods

We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers and 63 healthy controls. In addition, cervical cord cross-sectional areas were determined at 2 levels.

Res

SUBMITTER: Faber J 

PROVIDER: S-EPMC9521507 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature