Dataset Information

Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19.

ABSTRACT:

Background

Patients with COVID-19 receiving mechanical ventilation may become aggravated with a secondary respiratory infection. The aim of this study was to describe secondary respiratory infections, their predictive factors, and outcomes in patients with COVID-19 requiring mechanical ventilation.

Methods

A cohort study was carried out in a single tertiary hospital in Santiago, Chile, from 1st June to 31st July 2020. All patients with COVID-19 admitted to the intensive care unit that required mechanical ventilation were included.

Results

A total of 175 patients were enrolled, of which 71 (40.6%) developed at least one secondary respiratory infection during follow-up. Early and late secondary infections were diagnosed in 1.7% and 31.4% respectively. Within late secondary infections, 88% were bacterial, 10% were fungal, and 2% were of viral origin. One-third of isolated bacteria were multidrug-resistant. Bivariate analysis showed that the history of corticosteroids used before admission and the use of dexamethasone during hospitalization were associated with a higher risk of secondary infections (p = 0.041 and p = 0.019 respectively). Multivariate analysis showed that for each additional day of mechanical ventilation, the risk of secondary infection increases 1.1 times (_adOR = 1.07; 95% CI 1.02-1.13, p = 0.008) CONCLUSIONS: Patients with COVID-19 admitted to the intensive care unit and requiring mechanical ventilation had a high rate of secondary infections during their hospital stay. The number of days on MV was a risk factor for acquiring secondary respiratory infections.

SUBMITTER: Ceballos ME

PROVIDER: S-EPMC9521562 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19.

Ceballos María Elena ME Nuñez Carolina C Uribe Javier J Vera María Magdalena MM Castro Ricardo R García Patricia P Arriata Gabriel G Gándara Vicente V Vargas Camila C Dominguez Angélica A Cerón Inés I Born Pablo P Espíndola Eduardo E

BMC infectious diseases 20220929 1

<h4>Background</h4>Patients with COVID-19 receiving mechanical ventilation may become aggravated with a secondary respiratory infection. The aim of this study was to describe secondary respiratory infections, their predictive factors, and outcomes in patients with COVID-19 requiring mechanical ventilation.<h4>Methods</h4>A cohort study was carried out in a single tertiary hospital in Santiago, Chile, from 1st June to 31st July 2020. All patients with COVID-19 admitted to the intensive care unit ...[more]

PMID: 36175841

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Dataset Information

Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19.

Background

Methods

Results

Publications

Secondary respiratory early and late infections in mechanically ventilated patients with COVID-19.

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