Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation.

ABSTRACT: Liver transplantation is the only treatment available for pediatrics with end-stage liver disease. However, neurological damage is prone to occur after liver transplantation, especially in children. Accumulating evidence has shown that sevoflurane is closely linked to brain injury induced by liver transplantation. However, the study on the role of sevoflurane in brain injury induced by liver transplantation is rare and needs to be further investigated. The study is aiming to investigate the effects of sevoflurane on brain injury induced by liver transplantation and its underlying mechanisms. The brain injury rat model was built through 70% hepatic ischemia-reperfusion (HIR) of young rats. We detected the ferroptosis and brain injury after HIR by histological, transmission electron microsco

SUBMITTER: Yu X 

PROVIDER: S-EPMC9521585 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature