Cardiac magnetic resonance defines mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy.

ABSTRACT:

Background

Mechanisms of sex-based differences in outcomes following cardiac resynchronization therapy (CRT) are poorly understood.

Objective

To use cardiac magnetic resonance (CMR) to define mechanisms of sex-based differences in outcomes after CRT and describe distinct CMR-based phenotypes of CRT candidates based on sex and non-ischemic/ischemic cardiomyopathy type.

Materials and methods

In a prospective study, sex-based differences in three short-term CRT response measures [fractional change in left ventricular end-systolic volume index 6 months after CRT (LVESVI-FC), B-type natriuretic peptide (BNP) 6 months after CRT, change in peak VO₂ 6 months after CRT], and long-term survival were evaluated with respect to 39 baseline parameters from CMR, exercise

SUBMITTER: Bivona DJ 

PROVIDER: S-EPMC9521735 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature