Distinct loiasis infection states and associated clinical and hematological manifestations in patients from Gabon.

ABSTRACT:

Background

Loiasis-a filarial disease endemic in Central and West Africa-is increasingly recognized as significant individual and public health concern. While the understanding of the disease characteristics remains limited, significant morbidity and excess mortality have been demonstrated. Here, we characterize clinical and hematological findings in a large cohort from Gabon.

Methods

Loiasis-related clinical manifestations and microfilaremia, hemoglobin and differential blood counts were recorded prospectively during a cross-sectional survey. For analysis, participants were categorized into distinct infection states by the diagnostic criteria of eye worm history and microfilaremia.

Results

Analysis of data from 1,232 individuals showed that occurrence of clinical and

SUBMITTER: Veletzky L 

PROVIDER: S-EPMC9521832 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature