The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial.

ABSTRACT:

Background

The ventilatory ratio (VR, [minute ventilation × PaCO₂]/[predicted body weight × 100 × 37.5]) is associated with mortality in ARDS. The aims of this study were to test whether baseline disease severity or neuromuscular blockade (NMB) modified the relationship between VR and mortality.

Methods

This was a post hoc analysis of the PETAL-ROSE trial, which randomized moderate-to-severe ARDS patients to NMB or control. Survival among patients with different VR trajectories or VR cutoff above and below the median was assessed by Kaplan-Meier analysis. The relationships between single-day or 48-h VR trajectories with 28- or 90-day mortality were tested by logistic regression. Randomization allocation to NMB and markers of disease severity were tested as confoun

SUBMITTER: Monteiro ACC 

PROVIDER: S-EPMC9521854 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature