Design of a multi-epitope vaccine against the pathogenic fungi Candida tropicalis using an in silico approach.

ABSTRACT:

Background

Candida tropicalis causes tropical invasive fungal infections, with a high mortality. This fungus has been found to be resistant to antifungal classes such as azoles, echinocandins, and polyenes in several studies. As a result, it is vital to identify novel approaches to prevent and treat C. tropicalis infections. In this study, an in silico technique was utilized to deduce and evaluate a powerful multivalent epitope-based vaccine against C. tropicalis, which targets the secreted aspartic protease 2 (SAP2) protein. This protein is implicated in virulence and host invasion.

Results

By focusing on the Sap2 protein, 11 highly antigenic, non-allergic, non-toxic, and conserved epitopes were identified. These were subsequently paired with RS09 and flagellin adjuvants, a

SUBMITTER: Akhtar N 

PROVIDER: S-EPMC9521867 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature