Progranulin aggravates lethal Candida albicans sepsis by regulating inflammatory response and antifungal immunity.

ABSTRACT: Candida albicans is the most frequent pathogen of fungal sepsis associated with substantial mortality in critically ill patients and those who are immunocompromised. Identification of novel immune-based therapeutic targets from a better understanding of its molecular pathogenesis is required. Here, we reported that the production of progranulin (PGRN) levels was significantly increased in mice after invasive C.albicans infection. Mice that lacked PGRN exhibited attenuated kidney injury and increased survival upon a lethal systemic infection with C. albicans. In mice, PGRN deficiency protected against systemic candidiasis by decreasing aberrant inflammatory reactions that led to renal immune cell apoptosis and kidney injury, and by enhancing antifungal capacity of macrophages and neutrophil

SUBMITTER: Liu J 

PROVIDER: S-EPMC9521894 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature