Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study.

ABSTRACT:

Background

Post-acute sequelae of COVID-19 (PASC) includes a heterogeneous group of patients with variable symptomatology, who may respond to different therapeutic interventions. Identifying phenotypes of PASC and therapeutic strategies for different subgroups would be a major step forward in management.

Methods

In a prospective cohort study of patients hospitalized with COVID-19, 12-month symptoms and quantitative outcome metrics were collected. Unsupervised hierarchical cluster analyses were performed to identify patients with: (1) similar symptoms lasting ≥4 weeks after acute SARS-CoV-2 infection, and (2) similar therapeutic interventions. Logistic regression analyses were used to evaluate the association of these symptom and therapy clusters with quantitative 12-month ou

SUBMITTER: Frontera JA 

PROVIDER: S-EPMC9521913 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature