Initiation of wound healing is regulated by the convergence of mechanical and epigenetic cues.

ABSTRACT: Wound healing in the skin is a complex physiological process that is a product of a cell state transition from homeostasis to repair. Mechanical cues are increasingly being recognized as important regulators of cellular reprogramming, but the mechanism by which it is translated to changes in gene expression and ultimately cellular behavior remains largely a mystery. To probe the molecular underpinnings of this phenomenon further, we used the down-regulation of caspase-8 as a biomarker of a cell entering the wound healing program. We found that the wound-induced release of tension within the epidermis leads to the alteration of gene expression via the nuclear translocation of the DNA methyltransferase 3A (DNMT3a). This enzyme then methylates promoters of genes that are known to be down-regu

SUBMITTER: Bhatt T 

PROVIDER: S-EPMC9522318 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature