Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors.

ABSTRACT: Acute oxygen (O₂) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with restricted exchange of gases in the lung. The main acute O₂-sensing organ is the carotid body (CB), which contains neurosecretory chemoreceptor (glomus) cells innervated by sensory fibers whose activation by hypoxia elicits hyperventilation and increased cardiac output. Glomus cells have mitochondria with specialized metabolic and electron transport chain (ETC) properties. Reduced mitochondrial complex (MC) IV activity by hypoxia leads to production of signaling molecules (NADH and reactive O₂ species) in MCI and MCIII that modulate membrane ion channel activity. We studied mice with conditional genetic ablation of MCIII that disrupts the ET

SUBMITTER: Cabello-Rivera D 

PROVIDER: S-EPMC9522341 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature