Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors.

ABSTRACT: Inositol 1,4,5-trisphosphate receptors (IP₃Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca²⁺) signals in response to various external cues. Notably, IP₃R channel activity is determined by several obligatory factors, including IP₃, Ca²⁺, and ATP. The critical basic amino acid residues in the N-terminal IP₃-binding core (IBC) region that facilitate IP₃ binding are well characterized. In contrast, the residues conferring regulation by Ca²⁺ have yet to be ascertained. Using comparative structural analysis of Ca²⁺-binding sites identified in two main families of intracellular Ca²⁺-release channels, ryanodine receptors (RyRs) a

SUBMITTER: Arige V 

PROVIDER: S-EPMC9522344 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature