Retinoic acid and RARγ maintain satellite cell quiescence through regulation of translation initiation.

ABSTRACT: In adult skeletal muscle, satellite cells are in a quiescent state, which is essential for the future activation of muscle homeostasis and regeneration. Multiple studies have investigated satellite cell proliferation and differentiation, but the molecular mechanisms that safeguard the quiescence of satellite cells remain largely unknown. In this study, we purposely activated dormant satellite cells by using various stimuli and captured the in vivo-preserved features from quiescence to activation transitions. We found that retinoic acid signaling was required for quiescence maintenance. Mechanistically, retinoic acid receptor gamma (RARγ) binds to and stimulates genes responsible for Akt dephosphorylation and subsequently inhibits overall protein translation initiation in satellite cells. F

SUBMITTER: Luo W 

PROVIDER: S-EPMC9522790 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature