Development and validation of ⁶⁸Ga-PSMA-11 PET/CT-based radiomics model to detect primary prostate cancer.

ABSTRACT:

Background

This study aimed to develop a novel analytic approach based on a radiomics model derived from ⁶⁸Ga-prostate-specific membrane antigen (PSMA)-11 PET/CT for predicting intraprostatic lesions in patients with prostate cancer (PCa).

Methods

This retrospective study included consecutive patients with or without PCa who underwent surgery or biopsy after ⁶⁸Ga-PSMA-11 PET/CT. A total of 944 radiomics features were extracted from the images. A radiomics model was constructed using the least absolute shrinkage and selection operator (LASSO) algorithm with tenfold cross-validation in the training set. PET/CT images for the test set were reviewed by experienced nuclear medicine radiologists. The sensitivity, specificity, positive predictive value, negati

SUBMITTER: Zang S 

PROVIDER: S-EPMC9522942 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature