The short-term and long-term effects of intranasal mesenchymal stem cell administration to noninflamed mice lung.

ABSTRACT: Mesenchymal stem cells (mesenchymal stromal cells; MSC)-based therapies remain a promising approach to treat degenerative and inflammatory diseases. Their beneficial effects were confirmed in numerous experimental models and clinical trials. However, safety issues concerning MSCs' stability and their long-term effects limit their implementation in clinical practice, including treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease, and COVID-19. Here, we aimed to investigate the safety of intranasal application of human adipose tissue-derived MSCs in a preclinical experimental mice model and elucidate their effects on the lungs. We assessed short-term (two days) and long-term (nine days) effects of MSCs administration on lung morphology, immune responses, ep

SUBMITTER: Tynecka M 

PROVIDER: S-EPMC9523259 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature