Genetic effects of iron levels on liver injury and risk of liver diseases: A two-sample Mendelian randomization analysis.

ABSTRACT:

Background and aims

Although iron homeostasis has been associated with liver function in many observational studies, the causality in this relationship remains unclear. By using Mendelian Randomization analyses, we aimed to evaluate the genetic effects of increased systemic iron levels on the risk of liver injury and various liver diseases. Moreover, in light of the sex-dependent iron regulation in human beings, we further estimated the sex-specific effect of iron levels in liver diseases.

Methods

Independent single nucleotide polymorphisms associated with systemic iron status (including four indicators) at the genome-wide significance level from the Genetics of Iron Status (GIS) Consortium were selected as instrumental variables. Summary data for six liver function biomarke

SUBMITTER: Wang K 

PROVIDER: S-EPMC9523310 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature