Molecular characterisation and epidemiology of transmission of intraoperative Staphylococcus aureus isolates stratified by vancomycin minimum inhibitory concentration (MIC).

ABSTRACT:

Background

Reduced vancomycin susceptibility in Staphylococcus aureus (S. aureus) is considered a more pathogenic strain characteristic and is associated with treatment failure. We aimed to characterise the epidemiology of intraoperative transmission of S. aureus isolates with reduced vancomycin susceptibility.

Methods

S. aureus isolates (N=173) collected from 274 randomly selected operating room environments at three major academic medical centres in 2009-2010 were characterised by vancomycin minimum inhibitory concentration (MIC). We aimed to characterise the transmission dynamics for VISA and isolates with relatively reduced vancomycin (MIC= 2μg/mL) susceptibility at the range of therapeutic differentiation.

Results

Intraoperative S. 

SUBMITTER: Hadder B 

PROVIDER: S-EPMC9523349 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature