Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes.

ABSTRACT: Here, we found that heterozygous null of peroxisomal Nudt7 (Nudt7 ^+/- ) induced the typical NAFLD features, i.e. increased levels of hepatic triglyceride (TG) and fatty acid (FA), infiltration of inflammatory cells, impaired glucose tolerance and insulin sensitivity, and stimulation of lipolysis from adipose tissue. Particularly, in Nudt7 ^+/- hepatocytes, de novo lipogenesis (DNL) was significantly increased. Ingenuity pathway analysis (IPA) and KEGG pathway analysis of RNA sequencing data suggested the activation of PPAR signaling in the liver of Nudt7 ^+/- mice. Moreover, accumulation of palmitic acid in Nudt7 ^+/- hepatocyte increased the level of H3K4me3 on the promote

SUBMITTER: Song J 

PROVIDER: S-EPMC9523354 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature