Dissecting genetic links between Alzheimer's disease and type 2 diabetes mellitus in a systems biology way.

ABSTRACT: Background: Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most common diseases for older adults. Accumulating epidemiological studies suggest that T2DM is a risk factor for cognitive dysfunction in the elderly. In this study, we aimed to dissect the genetic links between the two diseases and identify potential genes contributing the most to the mechanistic link. Methods: Two AD (GSE159699 and GSE28146) and two T2DM (GSE38642 and GSE164416) datasets were used to identify the differentially expressed genes (DEGs). The datasets for each disease were detected using two platforms, microarray and RNA-seq. Functional similarity was calculated and evaluated between AD and T2DM DEGs considering semantic similarity, protein-protein interaction, and biologi

SUBMITTER: Kang P 

PROVIDER: S-EPMC9523408 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature