Epithelial Autoantigen-Specific IgG Antibody Enhances Eosinophil Extracellular Trap Formation in Severe Asthma.

ABSTRACT:

Purpose

There have been autoimmune mechanisms for the pathogenesis of severe asthma (SA) involving epithelial autoantigen-specific antibodies. This study aimed to find the function of these antibodies in the formation of eosinophil extracellular traps (EETs), contributing to the development of SA.

Methods

Patients with SA (n = 11), those with patients with nonsevere asthma (NSA, n = 41), and healthy controls (HCs, n = 26) were recruited to evaluate levels of epithelial antigens and autoantigen-specific antibodies. Moreover, the significance of epithelial autoantigen-specific antibodies in association with EET production was investigated ex vivo and in vivo.

Results

Significantly higher levels of serum cytokeratin (CK) 18 and CK18-specific IgG were observ

SUBMITTER: Lee DH 

PROVIDER: S-EPMC9523418 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature