Prescribing Characteristics Associated With Opioid Overdose Following Buprenorphine Taper.

ABSTRACT:

Importance

Retention in buprenorphine therapy is associated with a lower risk of opioid overdose. Nevertheless, many patients discontinue treatment, and there is limited evidence to guide buprenorphine tapering.

Objective

To understand what prescribing characteristics are associated with opioid overdose following buprenorphine taper.

Design, setting, and participants

This is a population-based, retrospective, cohort study of adults who were maintained on buprenorphine for at least 60 days and underwent a buprenorphine taper. The study was conducted in the Canadian province of Ontario, using linked administrative health data. New buprenorphine treatment episodes were accrued between January 1, 2013, and January 1, 2019, and the maximum follow-up was April 30, 2020. Dat

SUBMITTER: Bozinoff N 

PROVIDER: S-EPMC9523505 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature