Osteoporosis is associated with elevated baseline cerebrospinal fluid biomarkers and accelerated brain structural atrophy among older people.

ABSTRACT:

Objective

The aim of this study was to examine whether osteoporosis (OP) is associated with Alzheimer's disease-related cerebrospinal fluid (CSF) biomarkers and brain structures among older people.

Methods

From the Alzheimer's disease Neuroimaging Initiative database, we grouped participants according to the OP status (OP+/OP-) and compared the Alzheimer's disease (AD)-related CSF biomarker levels and the regional brain structural volumes between the two groups using multivariable models. These models were adjusted for covariates including age, education, gender, diagnosis of Alzheimer's disease, and apolipoprotein E4 carrier status.

Results

In the cross-sectional analyses at baseline, OP was related to higher CSF t-tau (total tau) and p-tau₁₈₁ (tau phospho

SUBMITTER: Pan H 

PROVIDER: S-EPMC9523506 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature