CT-based radiomic nomogram for preoperative prediction of DNA mismatch repair deficiency in gastric cancer.

ABSTRACT:

Background

DNA mismatch repair (MMR) deficiency has attracted considerable attention as a predictor of the immunotherapy efficacy of solid tumors, including gastric cancer. We aimed to develop and validate a computed tomography (CT)-based radiomic nomogram for the preoperative prediction of MMR deficiency in gastric cancer (GC).

Methods

In this retrospective analysis, 225 and 91 GC patients from two distinct hospital cohorts were included. Cohort 1 was randomly divided into a training cohort (n = 176) and an internal validation cohort (n = 76), whereas cohort 2 was considered an external validation cohort. Based on repeatable radiomic features, a radiomic signature was constructed using the least absolute shrinkage and selection operator (LASSO) regression analysis. We emplo

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC9523515 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature