Biophysical analysis of gelatin and PLGA nanoparticle interactions with complex biomimetic lung surfactant models.

ABSTRACT: Biocompatible materials are increasingly used for pulmonary drug delivery, and it is essential to understand their potential impact on the respiratory system, notably their effect on lung surfactant, a monolayer of lipids and proteins, responsible for preventing alveolar collapse during breathing cycles. We have developed a complex mimic of lung surfactant composed of eight lipids mixed in ratios reported for native lung surfactant. A synthetic peptide based on surfactant protein B was added to better mimic the biological system. This model was used to evaluate the impact of biocompatible gelatin and poly(lactic-co-glycolic acid) nanoparticles. Surface pressure-area isotherms were used to assess lipid packing, film compressibility and stability, whereas the lateral organization was visuali

SUBMITTER: Daear W 

PROVIDER: S-EPMC9523518 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature