Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality.

ABSTRACT:

Background

Prostate cancer is a clinically heterogeneous disease with a subset of patients rapidly progressing to lethal-metastatic prostate cancer. Current clinicopathological measures are imperfect predictors of disease progression. Epigenetic changes are amongst the earliest molecular changes in tumourigenesis. To find new prognostic biomarkers to enable earlier intervention and improved outcomes, we performed methylome sequencing of DNA from patients with localised prostate cancer and long-term clinical follow-up.

Methods

We used whole-genome bisulphite sequencing (WGBS) to comprehensively map and compare DNA methylation of radical prostatectomy tissue between patients with lethal disease (n = 7) and non-lethal (n = 8) disease (median follow-up 19.5 years). Validation of

SUBMITTER: Pidsley R 

PROVIDER: S-EPMC9523674 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature